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2 edition of Disruption of glycogen synthase kinase-3[Beta] in mice. found in the catalog.

Disruption of glycogen synthase kinase-3[Beta] in mice.

Juan Luo

Disruption of glycogen synthase kinase-3[Beta] in mice.

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  • 18 Currently reading

Published .
Written in English


The Physical Object
Pagination197 leaves.
Number of Pages197
ID Numbers
Open LibraryOL19086877M
ISBN 100612691802

  Free Online Library: Wound healing activity and docking of glycogen-synthase-kinase[beta]-protein with isolated triterpenoid lupeol in rats.(Report) by "Phytomedicine: International Journal of Phytotherapy & Phytopharmacology"; Health, general Biological sciences Science and technology, general Bittersweet Chemical properties Health aspects Research .   Alzheimer’s disease (AD) is defined by the excessive accumulation of toxic peptides, such as beta amyloid (Aβ) plaques and intracellular neurofibrillary tangles (NFT). The risk factors associated with AD include genetic mutations, aging, insulin resistance, and oxidative stress. To date, several studies that have demonstrated an association between AD and Cited by: 4. 1. Asavapanumas N, Ratelade J, Verkman AS: Unique neuromyelitis optica pathology produced in naïve rats by intracerebral administration of NMO-IgG. Acta Neuropathol; Apr;


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Disruption of glycogen synthase kinase-3[Beta] in mice. by Juan Luo Download PDF EPUB FB2

Dysregulation of glycogen synthase kinasebeta (GSK-3β) signaling pathways is thought to underlie the pathophysiology of mood disorders. In order to demonstrate that the loss of normal GSK-3β activity results in disturbances of physiological measures, we attempted to determine whether sleep–wake architecture, circadian rhythms of core body temperature and activity Cited by:   1.

PLoS One. Apr 12;14(4):e doi: / eCollection Targeted disruption of glycogen synthase kinase-3β in cardiomyocytes attenuates cardiac parasympathetic dysfunction in type 1 diabetic Akita : Yali Zhang, Charles M.

Welzig, Charles M. Welzig, Marian Haburcak, Bo Wang, Mark Aronovitz, Robert M. INTRODUCTION. Glycogen synthase kinase 3 (GSK3), a serine/threonine protein kinase, is a key component of a large number of cellular processes, including glucose regulation, inflammation, and immune responses, proliferation, migration, and apoptosis (see reviews [1, 2]).GSK3 is expressed in virtually all mammalian Disruption of glycogen synthase kinase-3[Beta] in mice.

book, and is encoded by two genes that Cited by: Disruption of glycogen synthase kinasebeta activity leads to abnormalities in physiological measures in mice Article in Behavioural brain research (1). Yoshino, Y., Ishioka, C. Inhibition of glycogen synthase kinase-3 beta induces Disruption of glycogen synthase kinase-3[Beta] in mice.

book and mitotic catastrophe by disrupting centrosome regulation in cancer cells. Sci Rep 5, (). https Cited by: Glycogen synthase kinase-3 (GSK-3)-α and -β are closely related protein-serine kinases, which act as inhibitory components of Wnt signalling during embryonic development and cell Cited by:   Glycogen synthase kinases 3 (GSK3) alpha and beta are expressed in the nervous system, and disruption of GSK3 signaling has been implicated in a wide range of neurodevelopmental and psychiatric disorders.

Although several studies have established a role of GSK3 signaling in the nervous system, much less is known about isoform-specific by: 6.

Glycogen synthase kinase-3 (GSK-3)-α and -β are closely related protein-serine kinases, which act as inhibitory components of Wnt signalling during Disruption of glycogen synthase kinase-3[Beta] in mice. book development and cell. Glycogen synthase kinase-3 beta (GSK-3 beta) regulates cell metabolism, cell cycle, and cell fate through the phosphorylation of a diverse array of substrates.

Stoothoff WH, Cho JH, McDonald RP, Johnson GV. FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation. J Biol Chem. ; – Woodgett JR. Molecular cloning and expression of glycogen synthase kinase-3/factor Disruption of glycogen synthase kinase-3[Beta] in mice.

book. Embo J. ; Cited by: Mice were injected intraperitoneally with 30 mg/kg kainate and hippocampal protein extracts were analyzed at different time intervals with phospho-specific antibodies which recognize active Akt, phosphorylated at S, and inactive GSK-3β, phosphorylated at S9, as shown in Fig.

In the untreated hippocampus, we found a basal level of Akt and GSK-3β phosphorylation indicating Cited by:   Perez DI, Pistolozzi M, Palomo V, Redondo M, Fortugno C, Gil C. et al. 5-Imino-1,thiadiazoles and quinazolines derivatives as glycogen synthase kinase 3 beta (GSK-3 beta) and phosphodiesterase 7 (PDE7) inhibitors: Determination of blood-brain barrier penetration and binding to human serum albumin.

Eur J Pharm Sci. ; –Cited by: Glycogen synthase kinase-3 β (GSK-3 β) is known to affect a diverse range of biological functions controlling gene expression, cellular architecture, and apoptosis.

GSK-3 β has recently been identified as one of the important pathogenic mechanisms in motor neuronal death related to amyotrophic lateral sclerosis (ALS).Cited by: 4. Glycogen synthase kinase 3 beta, also known as GSK3B, is an enzyme that in humans is encoded by the GSK3B gene.

[5] [6] In mice, the enzyme Disruption of glycogen synthase kinase-3[Beta] in mice. book encoded by the GSK-3β gene. [7] Abnormal regulation and expression of GSK3β is associated with an increased susceptibility towards bipolar s: GSK3B, Gsk3b, F15Rik.

We investigated the antinociceptive effects of AR-A, a selective inhibitor of glycogen synthase kinase-3β (GSK-3β) in mice. A minute pretreatment with AR-A .1 and 1 mg/kg, intraperitoneal [ip]) inhibited nociception induced by an ip injection of acetic by: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1.

Glycogen synthase (UDP-glucose-glycogen glucosyltransferase) is a key enzyme in glycogenesis, the conversion of glucose into glycogen. It is a glycosyltransferase (EC ) that catalyses the reaction of UDP-glucose and (1,4- α -D-glucosyl) n to yield UDP and (1,4- α -D-glucosyl) n+1.

5 Clinical significance. Model : BRENDA entry. Glycogen synthase kinase 3 (GSK3), in its two isoforms GSK3α and GSK3β, is a multifunctional Ser/Thr kinase found in eukaryotes [].This enzyme phosphorylates and regulates the function of more than 50 substrates [] and it is a point of convergence for numerous cell-signaling pathways involved in various essential cellular functions, such as glycogen Cited by: C.

Sutherland, I.A. Leighton, P. CohenInactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling The Biochemical journal, (Pt 1) (), pp. Cited by: For further exploring the factors involved in the induction of T phosphorylation of Cyclin D1 by wogonin, a variety of the related kinases such as the glycogen synthase kinase-3beta (GSK-3beta), IκB kinase α (IKKα) and extracellular signal–regulated kinases1/2 (ERK1/2) were analyzed by western blot assay (Mukherji et al., ).

As a Author: Ming Hong, Mohammed M. Almutairi, Siying Li, Jinke Li. Glycogen Synthase Kinase-3 Beta Current Cancer Drug Targets,Vol. 7, No. 3 5 It is widely recognised that GSK-3 β regulates the turnover of β -catenin in cells.

glycogen synthase kinase 3 beta Synonyms F15Rik, H08Rik, GSK3, GSK-3, GSK-3beta. The Akt–GSK3 signalling pathway. Glycogen synthase kinase-3 and Akt, also known as protein kinase B, are serine threonine kinases that were initially identified as playing a role in the regulation of glycogen synthesis in response to insulin receptor stimulation.

23 – 25 Over the years, these molecules were shown to be involved in a host of normal and pathologic Cited by: Glycogen synthase kinase 3 is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues.

First discovered in as a regulatory kinase for its namesake, Glycogen synthase, GSK-3 has since been identified as a kinase for over different proteins in a variety of different : cd   Here, we identified DISC1 as a major player controlling pancreatic β-cell proliferation and insulin secretion via regulation of glycogen synthase kinase-3β (GSK3β).

DISC1 expression was enriched in developing mouse and human pancreas and adult β- Cited by: Glycogen synthase kinase-3 (GSK-3) is a protein-serine kinase implicated in the hormonal control of several regulatory proteins including glycogen synthase and the transcription factor c.

Read "Disruption of glycogen synthase kinasebeta activity leads to abnormalities in physiological measures in mice, Behavioural Brain Research" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

GSK3B is a serine-threonine kinase that belongs to the glycogen synthase kinase subfamily. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation.

Polymorphisms in the GSK3B gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of the GSK3B gene may.

Glycogen synthase kinase-3 (GSK3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase (see GYS1, ).Two isoforms, alpha (GSK3A; ) and beta, show a high degree of amino acid homology (Stambolic and Woodgett, ).GSK3B is involved in energy metabolism, neuronal.

Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene. Glycogen synthase kinase 3-alpha EC is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase and various transcription factors (e.g., JUN).Aliases: GSK3A, Gsk3a, H06Rik.

Bijur GN, Jope RS () Glycogen synthase kinase-3 beta is highly activated in nuclei and mitochondria. Neurorep – [53] Cohen P, Goedert M () GSK3 inhibitors: Development and therapeutic potential. Nat Rev Drug Discov 3, – [54]Cited by: 8. MGI NCBI Gene: Gene Overview. : GSK3A IPR Glycogen synthase kinase 3, catalytic domain.

IPR Protein kinase Takahara S, et al., New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to beta-adrenergic stimulation-induced cardiac fibrosis.

EBioMedicine. Sperm motility is regulated by protein phosphorylation. We have shown that the signaling kinase, glycogen synthase kinase-3 alpha (GSK-3 alpha), is present in spermatozoa.

In somatic cells, GSK-3 is regulated by serine and tyrosine phosphorylation. In this report, we document that both GSK-3 alpha and GSK-beta isoforms are present in spermatozoa, with GSK-3 alpha being the.

Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated by glycogen synthase kinase-3, and extension of the N-terminal sequence containing the site phosphorylated by phosphorylase kinase.

Eur J Biochem ; – Cited by: Glycogen synthase kinase3 (GSK3) is emerging as a prominent drug target in the CNS. The most exciting of the possibilities of GSK3 lies within the treatment of Alzheimer's diseaseCited by:   Three of the other associated genes in this study also interact with the Wnt signaling pathway upstream and downstream of glycogen synthase kinase 3-beta (GSK3β).

Lithium-mediated inhibition of G. Glycogen synthase kinase-3{beta} (GSK-3{beta}) plays a central role in regulating circadian rhythms, and lithium is known to be a direct inhibitor of GSK-3{beta}. We designed a series of second generation benzofuranyl-(indolyl)maleimides containing a piperidine ring that possess IC{sub 50} values in the range of 4 to nM against human.

Dictyostelium homolog of glycogen synthase kinase 3 (GSK-3), and discovered that it is required for both cAMP effects. Disruption of gskA creates a mutant that aggregates but forms few spores and an abnormally high number of stalk cells. These stalk cells probably. Glycogen Synthase Kinase 3[beta] (GSK3[beta]) Plays a Major Role in Endoplasmic Reticulum (ER) Stress Induced Apoptosis in Mouse Insulinoma Cells GSK3[beta] has been implicated GSK3[beta] has been implicated in major cellular functions not limited to glycogen metabolism but also in cell growth and survival.

Disruption of the PPP1R3A gene encoding the glycogen targeting subunit (GM/RGL) of protein phosphatase 1 (PP1) causes substantial lowering of the glycogen synthase activity and a fold decrease in the glycogen levels in skeletal muscle. Homozygous GM−/− mice show increased weight gain after 3 months of age and become obese, weighing ∼20% Cited by:.

Aberrant activation NF-kappaB has been pdf as a mechanism of drug resistance in pancreatic cancer. Recently, inhibition of glycogen synthase kinase-3 has been shown to exert anti-tumor effects on pancreatic cancer cells by suppressing NF-kappaB. Consequently, we investigated whether inhibition of GSK-3 sensitizes pancreatic cancer cells Cited by: Glycogen synthase kinase-3{beta} (GSK3{beta}) is recognized as one of major kinases to phosphorylate tau in Alzheimer's disease (AD), thus lots of AD drug discoveries target GSK3{beta}.

However, the inactive form of GSK3{beta} which is phosphorylated at serine-9 is increased in AD brains.Glycogen Synthase Kinase Abnormalities and Therapeutic Potential ebook Fragile X Syndrome Jope, R.

S., May 26Fragile X Syndrome: From Genetics to Targeted Treatment. Elsevier, p. 15 p.